SYSTEMATIC CLASSIFICATION OF HIV BIOLOGICAL SUBTYPES ON LYMPHOCYTES AND MONOCYTES MACROPHAGES

被引：36

作者：

VONBRIESEN, H

ANDREESEN, R

RUBSAMENWAIGMANN, H

机构：

[1] CHEMOTHERAPEUT FORSCHUNGSINST GEORG SPEYER HAUS,PAUL EHRLICH STR 42-44,W-6000 FRANKFURT 70,GERMANY

[2] KLINIKUM ALBERT LUDWIG UNIV,MED KLIN,W-7800 PREIBURG,GERMANY

来源：

VIROLOGY | 1990年 / 178卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90361-T

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The growth properties and cytopathic effects of several HIV-1 and HIV-2 strains were compared between cultures on human lymphocytes and monocytes/macrophages, respectively. For some isolates (among these three paired isolates from blood and cerebrospinal fluid) replication and cytopathogenicity were comparable between lymphocytes and monocytes/macrophages (dual tropic viruses), while others showed a very specific tropism for only one cell type. Yet another subtype grew neither well on lymphocytes nor on macrophages. Taking into account the growth properties in monocytes/macrophages we propose a classification system for HIV subtypes on these cells (α-δ), in analogy to the nomenclature for HIV-subtyping on lymphocytes (a-d). Using this system, some prototypic viruses (LAV/HTLV-IIIB, HIV-2ROD, SIVBK28, HIV-2ALT) as well as several other HIV-1 and HIV-2 isolates were subtyped. © 1990.

引用

页码：597 / 602

页数：6

共 30 条

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