N-(ARYLALKYL)FARNESYLAMINES - NEW POTENT SQUALENE SYNTHETASE INHIBITORS

被引：32

作者：

PRASHAD, M ^{[1
]}

KATHAWALA, FG ^{[1
]}

SCALLEN, T ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT BIOCHEM,ALBUQUERQUE,NM 87131

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 10期

关键词：

D O I：

10.1021/jm00062a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1501 / 1504

页数：4

共 13 条

[1] THE 1ST POTENT INHIBITOR OF SQUALENE SYNTHASE - A PROFOUND CONTRIBUTION OF AN ETHER OXYGEN TO INHIBITOR ENZYME INTERACTION [J].

BILLER, SA ;

SOFIA, MJ ;

DELANGE, B ;

FORSTER, C ;

GORDON, EM ;

HARRITY, T ;

RICH, LC ;

CIOSEK, CP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (22) :8522-8524

[2] SYNTHESIS OF AMMONIUM ANALOGS OF CARBOCATIONIC INTERMEDIATES IN THE CONVERSION OF PRESQUALENE DIPHOSPHATE TO SQUALENE [J].

CAPSON, TL ;

THOMPSON, MD ;

DIXIT, VM ;

GAUGHAN, RG ;

POULTER, CD .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (25) :5903-5908

[3] A CONVENIENT PREPARATION OF FARNESYLAMINE [J].

COPPOLA, GM ;

PRASHAD, M .

SYNTHETIC COMMUNICATIONS, 1993, 23 (04) :535-541

[4] THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY [J].

DAWSON, MJ ;

FARTHING, JE ;

MARSHALL, PS ;

MIDDLETON, RF ;

ONEILL, MJ ;

SHUTTLEWORTH, A ;

STYLLI, C ;

TAIT, RM ;

TAYLOR, PM ;

WILDMAN, HG ;

BUSS, AD ;

LANGLEY, D ;

HAYES, MV .

JOURNAL OF ANTIBIOTICS, 1992, 45 (05) :639-647

[5] THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA .3. BIOSYNTHESIS [J].

JONES, CA ;

SIDEBOTTOM, PJ ;

CANNELL, RJP ;

NOBLE, D ;

RUDD, BAM .

JOURNAL OF ANTIBIOTICS, 1992, 45 (09) :1492-1498

[6] NUCLEOPHILIC REACTIVITY OF ZINC AND COPPER CARBENOIDS .2. [J].

KNOCHEL, P ;

CHOU, TS ;

CHEN, HG ;

YEH, MCP ;

ROZEMA, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (22) :5202-5204

[7] SQUALENE SYNTHETASE INHIBITORS - SYNTHESIS OF SULFONIUM ION MIMICS OF THE CARBOCATIONIC INTERMEDIATES [J].

OEHLSCHLAGER, AC ;

SINGH, SM ;

SHARMA, S .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (12) :3856-3861

[8] ALPHA ANIONS OF CARBOXYLIC-ACIDS .2. FORMATION AND ALKYLATION OF ALPHA-METALATED ALIPHATIC ACIDS [J].

PFEFFER, PE ;

SILBERT, LS ;

CHIRINKO, JM .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (03) :451-&

[9] SQUALENE SYNTHETASE - INHIBITION BY AMMONIUM ANALOGS OF CARBOCATIONIC INTERMEDIATES IN THE CONVERSION OF PRESQUALENE DIPHOSPHATE TO SQUALENE [J].

POULTER, CD ;

CAPSON, TL ;

THOMPSON, MD ;

BARD, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (10) :3734-3739

[10]

POULTER CD, 1981, BIOSYNTHESIS ISOPREN, V1, P414

← 1 2 →