ANTIBIOTIC PREPARATIONS CONTAIN DNA - A SOURCE OF DRUG-RESISTANCE GENES

被引：70

作者：

WEBB, V ^{[1
]}

DAVIES, J ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT MICROBIOL,VANCOUVER V6T 1Z3,BC,CANADA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 11期

关键词：

D O I：

10.1128/AAC.37.11.2379

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fluorescence measurements and polymerase chain reaction amplification of streptomycete 16S ribosomal DNA sequences were used to show that a number of antibiotic preparations employed for human and animal use are contaminated with chromosomal DNA of the antibiotic-producing organism. The DNA contains identifiable antibiotic resistance gene sequences; the uptake of this DNA by bacteria and its functional incorporation into bacterial replicons would lead to the generation of antibiotic resistance determinants. We propose that the presence of DNA encoding drug resistance in antibiotic preparations has been a factor in the rapid development of multiple antibiotic resistance in bacteria.

引用

页码：2379 / 2384

页数：6

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