CHROMOSOMES AND CAUSATION OF HUMAN CANCER AND LEUKEMIA .33. 5Q-IN A CASE OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

被引：31

作者：

ABE, S ^{[1
]}

KOHNO, S ^{[1
]}

KUBONISHI, I ^{[1
]}

MINOWADA, J ^{[1
]}

SANDBERG, AA ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,666 ELM ST,BUFFALO,NY 14263

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1979年 / 6卷 / 03期

关键词：

ALL; chromosomes; deletion;

D O I：

10.1002/ajh.2830060310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The case of a 4‐year‐old boy with ALL, possibly developing subsequent to a lymphoma involving the throacic cavity, which was shown to be of the T‐cell type, is presented. The leukemic cells had a 5q– anomaly, which had previously been described only in cases of refractory anemia and/or AML. The 5q– abnormality was invariably accompanied by a 9p– chromosome in the leukemic cells. The interstitial deletion leading to the 5q– chromosome was shown with banding techniques to be similar to that described previously in myeloproliferative disorders. Some aspects of the 5q– anomaly in ALL and its relation to previous experience with this karyotypic change are discussed. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：259 / 266

页数：8