FURFURAL AS A MARKER OF DNA CLEAVAGE BY HYDROXYLATION AT THE 5' CARBON OF DEOXYRIBOSE

被引：89

作者：

PRATVIEL, G

PITIE, M

BERNADOU, J

MEUNIER, B

机构：

[1] Laboratoire de Chimie de Coordination du, CNRS 205, Toulouse, F-31077, route de Narbonne

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 06期

关键词：

D O I：

10.1002/anie.199107021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Depending upon the type of DNA substrate, a manganoporphyrin/KHSO5 system as artificial nuclease preferably attacks at the C1' or C5' atom of the deoxyribose moiety, whereby subsequent heating of the reaction mixtures leads to release of 5-methylene-2-furanone (5-MF) and furfural (FUR). The ratio 5-MF/FUR directly reflects the relative reactivities of the cleaving reagent with respect to C1' and C5'. A possible reaction for the formation of FUR is outlined below. (GRAPHICS) = terminal phosphate residue, B = nucleobase.

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页码：702 / 704

页数：3

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