COMPARISON OF THE SENSITIVITY OF 3 TOXICITY TESTS DETERMINING SURVIVAL, INHIBITION OF GROWTH AND COLONY-FORMING ABILITY IN HUMAN FIBROBLASTS AFTER INCUBATION WITH ENVIRONMENTAL CHEMICALS

被引：9

作者：

WITTE, I ^{[1
]}

FRAHMANN, E ^{[1
]}

JACOBI, H ^{[1
]}

机构：

[1] CARL VON OSSIETZKY UNIV OLDENBURG,ICBM,D-26111 OLDENBURG,GERMANY

来源：

TOXICOLOGY IN VITRO | 1995年 / 9卷 / 03期

关键词：

D O I：

10.1016/0887-2333(94)00210-L

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The sensitivity of three methods measuring basal cytotoxicity in human fibroblasts was compared. Cell survival, inhibition of growth and colony-forming ability were measured after 1 hr of incubation with nine environmental chemicals from different substance classes. The sensitivity of the method of determining inhibition of growth was similar to that of the test of colony-forming ability and was double that of a commonly used method to determine cell survival. Linear regression analysis showed that the three methods correlated well with each other, the strongest correlation being between colony-forming ability and growth.

引用

页码：327 / 331

页数：5

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