SYNTHESIS AND BINDING-PROPERTIES OF A PEPTIDE RECEPTOR

被引：17

作者：

FLACK, SS ^{[1
]}

KILBURN, JD ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 19期

关键词：

D O I：

10.1016/0040-4039(95)00494-W

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrocyclic receptor 2, with an amidopyridine unit as the binding site for carboxylic acid functionality and amide functionality to provide additional hydrogen bonding sites, has been synthesised. Preliminary binding studies with 2 and various peptidic guests are described.

引用

页码：3409 / 3412

页数：4

共 9 条

[1]

ALBERT J, 1991, J CHEM SOC CHEM COMM, P1761

[2] ENANTIOSELECTIVE AND DIASTEREOSELECTIVE MOLECULAR RECOGNITION OF CYCLIC DIPEPTIDES BY A C-2 MACROLACTAM HOST [J].

CRISTOFARO, MF ;

CHAMBERLIN, AR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (12) :5089-5098

[3] MOLECULAR RECOGNITION - A REMARKABLY SIMPLE RECEPTOR FOR THE SELECTIVE COMPLEXATION OF DICARBOXYLIC-ACIDS [J].

GARCIATELLADO, F ;

GOSWAMI, S ;

CHANG, SK ;

GEIB, SJ ;

HAMILTON, AD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (20) :7393-7394

[4] SYNTHESIS OF AN UNNATURAL PRODUCT - 4,4' BIARYL FORMATION AS A MACROCYCLIZATION STEP [J].

PATEL, HK ;

KILBURN, JD ;

LANGLEY, GJ ;

EDWARDS, PD ;

MITCHELL, T ;

SOUTHGATE, R .

TETRAHEDRON LETTERS, 1994, 35 (03) :481-484

[5]

SCHNEIDER HJ, 1993, ANGEW CHEM INT EDIT, V32, P848, DOI 10.1002/anie.199308481

[6] THE PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOTIN REAGENTS WITH ORGANIC ELECTROPHILES [J].

STILLE, JK .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (06) :508-523

[7]

Wilcox C. S., 1991, FRONTIERS SUPRAMOLEC

[8] CHEMISTRY OF SYNTHETIC RECEPTORS AND FUNCTIONAL-GROUP ARRAYS .18. APPROACHES TO QUANTITATIVE SUPRAMOLECULAR CHEMISTRY - HYDROGEN-BOND-BASED MOLECULAR RECOGNITION PHENOMENA AND SIGMOIDAL BEHAVIOR IN MULTICOMPONENT MIXTURES [J].

WILCOX, CS ;

ADRIAN, JC ;

WEBB, TH ;

ZAWACKI, FJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (26) :10189-10197

[9] CYCLOOLIGOMERIC RECEPTORS FOR THE SEQUENCE SELECTIVE BINDING OF PEPTIDES - A TETRAHEDRAL RECEPTOR FROM TRIMESIC ACID AND 1,2-DIAMINES [J].

YOON, SS ;

STILL, WC .

TETRAHEDRON LETTERS, 1994, 35 (46) :8557-8560

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