SYNTHESIS OF AN UNNATURAL PRODUCT - 4,4' BIARYL FORMATION AS A MACROCYCLIZATION STEP

被引：14

作者：

PATEL, HK

KILBURN, JD

LANGLEY, GJ

EDWARDS, PD

MITCHELL, T

SOUTHGATE, R

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期

关键词：

D O I：

10.1016/0040-4039(94)85086-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel macrocyle featuring a crown ether ring, amide functionality and a rigid biaryl unit has been prepared as a potential receptor for small peptidic guests. The synthesis of the macrocyle includes a palladium catalysed biaryl formation as the ring-closing step.

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收藏

页码：481 / 484

页数：4

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