GONADAL-STEROIDS AS PROMOTERS OF NEURO-GLIAL PLASTICITY

被引:68
作者
GARCIASEGURA, LM [1 ]
CHOWEN, JA [1 ]
DUENAS, M [1 ]
TORRESALEMAN, I [1 ]
NAFTOLIN, F [1 ]
机构
[1] YALE UNIV, SCH MED, DEPT OBSTET & GYNECOL, NEW HAVEN, CT 06510 USA
关键词
ESTRADIOL; PROGESTERONE; TROPHIC FACTORS; GABA; ASTROGLIA; SYNAPTIC PLASTICITY;
D O I
10.1016/0306-4530(94)90031-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Estradiol induces coordinated modifications in the extension of glial and neuronal processes in the arcuate nucleus of the hypothalamus of adult female rats. This hormonal effect results in natural fluctuations in the ensheathing of arcuate neurons by glial processes and these glial changes are linked to a remodelling of inhibitory GABAergic synapses during the estrous cycle. Hormonally induced glial and synaptic changes appear to be dependent on specific recognition or adhesion molecules on the neuronal and/or glial membranes.
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页码:445 / 453
页数:9
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