EFFECTS OF PSORALEN PLUS UVA RADIATION (PUVA) ON HIV-1 IN HUMAN-BEINGS - A PILOT-STUDY

被引：31

作者：

HORN, TD

MORISON, WL

FARZADEGAN, H

ZMUDZKA, BZ

BEER, JZ

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD

[2] US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1994年 / 31卷 / 05期

关键词：

D O I：

10.1016/S0190-9622(94)70234-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Laboratory data document the activation of the HIV-1 genome on exposure to UV radiation, including PUVA. The overall effects of UV radiation exposure on HIV-1 infection in human beings are unknown. Objective: Our purpose was to observe CD4 cell counts and quantitative markers of HIV-1 load in late-stage HIV-1-infected human beings receiving PUVA for various cutaneous diseases. Methods: Samples of peripheral blood were obtained on days 0, 14, 30, and 60 of PUVA administered in therapeutic doses. Number of CD4(+) T lymphocytes was determined by flow cytometry, and HIV-1 load was measured by semiquantitative polymerase chain reaction for viral genome in peripheral blood mononuclear cells, semiquantitative RNA-polymerase chain reaction for HIV-1 RNA in serum, and determination of p24 in serum. Results: No significant changes in the measurements were observed. Conclusion: This study did not detect a deleterious effect on CD4 cell count or HIV-1 load during 2 months of PUVA treatment for patients in late stages of infection, with low CD4 cell counts and high HIV-1 loads.

引用

页码：735 / 740

页数：6

共 18 条

[11] INDUCTION OF EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS IN A CHRONICALLY INFECTED PROMONOCYTIC CELL-LINE BY ULTRAVIOLET-IRRADIATION [J].