SYNTHESIS OF SOME TRITIATED 5-SUBSTITUTED URACIL DERIVATIVES

被引：2

作者：

BARR, PJ ^{[1
]}

BOHACEK, L ^{[1
]}

JONES, AS ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] INST RES PROD & RADIOISOTOPES,PRAHA 7,CZECHOSLOVAKIA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 06期

关键词：

5‐acetyl[6‐[!sup]3[!/sup]H]uracil; 5‐[[!sup]3[!/sup]H‐ethynyl]uracil;

D O I：

10.1002/jlcr.2580160613

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 5‐[3H‐ethynyl]uracil and 5‐acetyl[6‐3H]uracil in good yield and of a medium specific activity ( > 40 mCi/mmol) is described. The compounds are necessary for following the incorporation of these and other derived 5‐substituted uracils into DNA and also for studying the metabolism and mode of action of their deoxynucleosides, some of which possess antiviral properties. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：909 / 915

页数：7