EFFECTS OF DORSAL RAPHE STIMULATION ON CEREBRAL GLUCOSE-UTILIZATION IN THE ANESTHETIZED RAT

被引：10

作者：

BONVENTO, G

LACOMBE, P

MACKENZIE, ET

SEYLAZ, J

机构：

[1] CNRS,RECH CEREBROVASC LAB,F-75005 PARIS,FRANCE

[2] CNRS,CEA,DSV DPTE,CAEN,FRANCE

来源：

BRAIN RESEARCH | 1991年 / 567卷 / 02期

关键词：

LOCAL CEREBRAL GLUCOSE UTILIZATION; C-14]2-DEOXYGLUCOSE; DORSAL RAPHE NUCLEUS; AUTORADIOGRAPHY; FLOW-METABOLISM COUPLING;

D O I：

10.1016/0006-8993(91)90813-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to determine the effects of electrical stimulation of the dorsal raphe nucleus on local cerebral glucose utilization (LCGU) in the alpha-chloralose anaesthetized rat. Activation of the dorsal raphe nucleus effected significant increases in LCGU, ranging from 13 to 52% in 8 brain structures out of 33 investigated. Increases were restricted to extrapyramidal and limbic non-specific areas, and no modifications were observed in cortical areas. The comparison with our previous results, showing that a similar raphe activation induced a global decrease in local cerebral blood flow, suggests that the ascending serotonergic system may be of importance in the regulation of the cerebral circulation.

引用

页码：325 / 327

页数：3

共 15 条

[1] AUTORADIOGRAPHIC ANALYSIS OF DIFFERENTIAL ASCENDING PROJECTIONS OF DORSAL AND MEDIAN RAPHE NUCLEI IN RAT
AZMITIA, EC
SEGAL, M
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 179 (03) : 641 - 667
[2] DIFFERENTIAL-EFFECTS OF ELECTRICAL-STIMULATION OF THE DORSAL RAPHE NUCLEUS AND OF CERVICAL SYMPATHECTOMY ON SEROTONIN AND NORADRENALINE CONCENTRATIONS IN MAJOR CEREBRAL-ARTERIES AND PIAL VESSELS IN THE RAT
BONVENTO, G
LACOMBE, P
MACKENZIE, ET
ROUQUIER, L
SCATTON, B
SEYLAZ, J
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (01) : 123 - 126
[3] EFFECTS OF ELECTRICAL-STIMULATION OF THE DORSAL RAPHE NUCLEUS ON LOCAL CEREBRAL BLOOD-FLOW IN THE RAT
BONVENTO, G
LACOMBE, P
SEYLAZ, J
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (03) : 251 - 255
[4] EVIDENCE FOR DIFFERING ORIGINS OF THE SEROTONERGIC INNERVATION OF MAJOR CEREBRAL-ARTERIES AND SMALL PIAL VESSELS IN THE RAT
BONVENTO, G
LACOMBE, P
MACKENZIE, ET
FAGE, D
BENAVIDES, J
ROUQUIER, L
SCATTON, B
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 56 (02) : 681 - 689
[5] SEROTONIN UPTAKE INTO CEREBROVASCULAR NERVE-FIBERS OF RAT, VISUALIZATION BY IMMUNOHISTOCHEMISTRY, DISAPPEARANCE FOLLOWING SYMPATHECTOMY, AND RELEASE DURING ELECTRICAL-STIMULATION
CHANG, JY
EKBLAD, E
KANNISTO, P
OWMAN, C
[J]. BRAIN RESEARCH, 1989, 492 (1-2) : 79 - 88
[6] SEROTONIN-SYNTHESIZING NERVE-FIBERS IN RAT AND CAT CEREBRAL-ARTERIES AND ARTERIOLES - IMMUNOHISTOCHEMISTRY OF TRYPTOPHAN-5-HYDROXYLASE
CHEDOTAL, A
HAMEL, E
[J]. NEUROSCIENCE LETTERS, 1990, 116 (03) : 269 - 274
[7] CUDENNEC A, 1989, J CEREB BLOOD FLO S1, V9, pS375
[8] CUDENNEC A, 1988, BRAIN RES, V244, P227
[9] CENTRAL SEROTONERGIC NERVES PROJECT TO THE PIAL VESSELS OF THE BRAIN
EDVINSSON, L
DEGUEURCE, A
DUVERGER, D
MACKENZIE, ET
SCATTON, B
[J]. NATURE, 1983, 306 (5938) : 55 - 57
[10] EVIDENCE FOR A POSSIBLE ROLE FOR SEROTONERGIC SYSTEMS IN THE CONTROL OF CEREBRAL BLOOD-FLOW
MCBEAN, DE
SHARKEY, J
RITCHIE, IM
KELLY, PAT
[J]. BRAIN RESEARCH, 1990, 537 (1-2) : 307 - 310

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