A DIRECT HPLC METHOD FOR THE RESOLUTION OF GLYCIDYL TOSYLATE AND GLYCIDYL 3-NITROBENZENESULPHONATE ENANTIOMERS

被引：11

作者：

SHAW, CJ

BARTON, DL

机构：

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 10-12期

关键词：

HPLC; GLYCIDYL TOSYLATE; GLYCIDYL; 3-NITROBENZENESULPHONATE; ENANTIOMERS;

D O I：

10.1016/0731-7085(91)80003-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The enantiomeric composition of glycidyl tosylate and glycidyl 3-nitrobenzenesulphonate is obtained using an enantiomeric HPLC column. The chiral oxiranes were resolved on a cellulose carbamate column using a mobile phase of hexane:2-propanol. The method is simple, sensitive and does not require derivatization.

引用

收藏

页码：793 / 796

页数：4

相关论文

共 10 条

[1] SHORT AND ENANTIOSELECTIVE SYNTHESES OF (R)-2-HYDROXYMETHYL-1,4-BENZODIOXAN AND (S)-2-HYDROXYMETHYL-1,4-BENZODIOXAN [J].

DELGADO, A ;

LECLERC, G ;

LOBATO, C ;

MAULEON, D .

TETRAHEDRON LETTERS, 1988, 29 (30) :3671-3674

[2] A CONVENIENT GAS-CHROMATOGRAPHIC METHOD FOR THE OPTICAL PURITY DETERMINATION OF CHIRAL EPOXY ALCOHOLS [J].

DOUGHERTY, W ;

LIOTTA, F ;

MONDIMORE, D ;

SHUM, W .

TETRAHEDRON LETTERS, 1990, 31 (31) :4389-4390

[3] DETERMINATION OF THE ENANTIOMERIC COMPOSITION OF CHIRAL EPOXIDES USING CHIRAL DERIVATIZATION AND LIQUID-CHROMATOGRAPHY [J].

GAL, J .

JOURNAL OF CHROMATOGRAPHY, 1985, 331 (02) :349-357

[4] REGIOSPECIFIC OPENING OF GLYCIDYL DERIVATIVES MEDIATED BY BORON-TRIFLUORIDE - ASYMMETRIC-SYNTHESIS OF ETHER-LINKED PHOSPHOLIPIDS [J].

GUIVISDALSKY, PN ;

BITTMAN, R .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (19) :4637-4642

[5] NOVEL ENANTIOSELECTIVE SYNTHESIS OF PLATELET ACTIVATING FACTOR AND ITS ENANTIOMER VIA RING-OPENING OF GLYCIDYL TOSYLATE WITH 1-HEXADECANOL [J].

GUIVISDALSKY, PN ;

BITTMAN, R .

TETRAHEDRON LETTERS, 1988, 29 (35) :4393-4396

[6] ARENESULFONATE DERIVATIVES OF HOMOCHIRAL GLYCIDOL - VERSATILE CHIRAL BUILDING-BLOCKS FOR ORGANIC-SYNTHESIS [J].

KLUNDER, JM ;

ONAMI, T ;

SHARPLESS, KB .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (06) :1295-1304

[7]

KLUNDER JM, 1986, J ORG CHEM, V51, P3170

[8]

SHARPLESS KB, 1990, Patent No. 4946974

[9]

Snyder LR, 1979, INTRO MODERN LIQUID, P34

[10] STEREOSELECTIVE FORMATION OF BENZ[A]ANTHRACENE (+)-(5S,6R)-OXIDE AND (+)-(8R,9S)-OXIDE BY A HIGHLY PURIFIED AND RECONSTITUTED SYSTEM CONTAINING CYTOCHROME P-450C [J].

VANBLADEREN, PJ ;

ARMSTRONG, RN ;

COBB, D ;

THAKKER, DR ;

RYAN, DE ;

THOMAS, PE ;

SHARMA, ND ;

BOYD, DR ;

LEVIN, W ;

JERINA, DM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 106 (02) :602-609