GENETIC DIVERSITY IN T1M1 GROUP-A STREPTOCOCCI IN RELATION TO CLINICAL OUTCOME OF INFECTION

被引:62
作者
NORGREN, M
NORRBY, A
HOLM, SE
机构
[1] Department of Clinical Bacteriology, University of Umeå
关键词
D O I
10.1093/infdis/166.5.1014
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Genetic diversity was found at high frequency downstream of the emm1 gene among T1M1 group A streptococci (GAS) isolated in Scandinavia during a recent epidemic. Clonal variation was also seen in the speA and speB genes but at much lower frequency, no variation was detected in the speC gene. Erythrogenic toxin A was found to be expressed at low levels in all strains; erythrogenic toxins B and C were produced in high amounts. All strains were found to harbor the speA, speB, and speC genes, regardless of the amount of toxin produced. No correlation was found between one specific T1M1 clone and the more serious infections when isolates from bacteremic patients (fatalities or survivors), those with uncomplicated infections, and healthy carriers were compared. Similar results were obtained in a family study in which 3 family members were found to be asymptomatic carriers of the same GAS T1M1 clone as in the bacteremic patient, defined by genotypic and phenotypic experiments.
引用
收藏
页码:1014 / 1020
页数:7
相关论文
共 29 条
[11]   MOLECULAR ANALYSIS OF PYROGENIC EXOTOXINS FROM STREPTOCOCCUS-PYOGENES ISOLATES ASSOCIATED WITH TOXIC SHOCK-LIKE SYNDROME [J].
HAUSER, AR ;
STEVENS, DL ;
KAPLAN, EL ;
SCHLIEVERT, PM .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (08) :1562-1567
[12]   NUCLEOTIDE-SEQUENCE OF THE STREPTOCOCCAL PYROGENIC EXOTOXIN TYPE-B GENE AND RELATIONSHIP BETWEEN THE TOXIN AND THE STREPTOCOCCAL PROTEINASE PRECURSOR [J].
HAUSER, AR ;
SCHLIEVERT, PM .
JOURNAL OF BACTERIOLOGY, 1990, 172 (08) :4536-4542
[13]  
HOLLINGSHEAD SK, 1986, J BIOL CHEM, V261, P1677
[14]   SIZE VARIATION IN GROUP-A STREPTOCOCCAL-M PROTEIN IS GENERATED BY HOMOLOGOUS RECOMBINATION BETWEEN INTRAGENIC REPEATS [J].
HOLLINGSHEAD, SK ;
FISCHETTI, VA ;
SCOTT, JR .
MOLECULAR & GENERAL GENETICS, 1987, 207 (2-3) :196-203
[15]  
HOLM SE, 1967, ACTA PATHOL MIC SC, V69, P264
[16]  
HOLM SE, 1989, J INFECT DIS, V166, P31
[17]   STREPTOCOCCAL PYROGENIC EXOTOXIN TYPE-A (SCARLET FEVER TOXIN) IS RELATED TO STAPHYLOCOCCUS-AUREUS ENTEROTOXIN-B [J].
JOHNSON, LP ;
LITALIEN, JJ ;
SCHLIEVERT, PM .
MOLECULAR & GENERAL GENETICS, 1986, 203 (02) :354-356
[18]   SPONTANEOUS M6-PROTEIN SIZE MUTANTS OF GROUP-A STREPTOCOCCI DISPLAY VARIATION IN ANTIGENIC AND OPSONOGENIC EPITOPES [J].
JONES, KF ;
HOLLINGSHEAD, SK ;
SCOTT, JR ;
FISCHETTI, VA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8271-8275
[19]  
JONES KF, 1989, 87TH ANN M AM SOC MI
[20]  
KOHLER W, 1990, ZBL BAKT-INT J MED M, V272, P257