SERUM FACTOR IN MILLER-FISHER VARIANT OF GUILLAIN-BARRE-SYNDROME AND NEUROTRANSMITTER RELEASE

被引:149
作者
ROBERTS, M
WILLISON, H
VINCENT, A
NEWSOMDAVIS, J
机构
[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOLEC MED,DEPT CLIN NEUROL,NEUROSCI GRP,OXFORD OX3 9DU,ENGLAND
[2] UNIV GLASGOW,SO GEN HOSP,INST NEUROL SCI,DEPT NEUROL,GLASGOW G51 4TF,SCOTLAND
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0140-6736(94)92694-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum IgG autoantibodies to GQ1b ganglioside are associated with the acute phase of the Miller-Fisher syndrome (MFS). We investigated the effects of three anti-GQ1b-positive MFS sera in the mouse phrenic-nerve/diaphragm preparation. Miniature endplate potential frequencies increased eight-fold within 25 min, declined rapidly, and ceased altogether after 3 h, when nerve stimulation no longer evoked a response. One MFS convalescent serum (anti-GQ1b negative) and sera from healthy controls and from patients with other neurological diseases were without effect. Thus muscle weakness in MFS may be caused by a serum factor, likely to be GQ1b antibody, that leads to failure of acetylcholine release from motor nerve terminals.
引用
收藏
页码:454 / 455
页数:2
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