SEROPREVALENCE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN ZAMBIAN CHILDREN WITH TUBERCULOSIS

被引:64
作者
CHINTU, C
BHAT, G
LUO, C
RAVIGLIONE, M
DIWAN, V
DUPONT, HL
ZUMLA, A
机构
[1] UNIV TEXAS,CTR INFECT DIS,SCH MED,HOUSTON,TX 77025
[2] UNIV TEXAS,SCH PUBL HLTH,HOUSTON,TX 77025
[3] WHO,TB PROGRAMME,CH-1211 GENEVA 27,SWITZERLAND
[4] KAROLINSKA INST,INT HLTH CARE RES,S-10401 STOCKHOLM 60,SWEDEN
关键词
ACQUIRED IMMUNODEFICIENCY SYNDROME; HUMAN IMMUNODEFICIENCY VIRUS; TUBERCULOSIS; SEROPREVALENCE; CHILDREN;
D O I
10.1097/00006454-199306000-00008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Descriptions in the medical literature of human immunodeficiency virus type 1 (HIV-1) in children with tuberculosis (TB) are scanty. This study determined the seroprevalence of HIV-1 in 237 hospitalized children between the ages of 1 month and 14 years with a clinical diagnosis of TB (125 males and 112 females) and in 242 control children (149 males and 93 females). The overall HIV-1 seroprevalence rate in patients with TB was 37% (88 of 237) compared with 10.7% (26 of 242) among the control group (P < 0.00001: odds ratio 5.37, 95% confidence interval = 3.21 < 5.37 < 9.47). HIV-1 seropositivity in children with TB ranged from 53% (31 of 58) in the 12- to 18-month age group to 14% (9 of 61) in the 10- to 14-year-olds. The risk of TB attributable to HIV infection was 29%. The predominant clinical presentation in both seronegative (84.6%) and seropositive (89.7%) groups was that of pulmonary TB and there were no significant differences in clinical presentation between the two groups of patients. Only 54.8% of the patients attended follow-up clinics regularly whereas 32% were lost to follow-up within 3 months. Bacillus Calmette-Guerin vaccination coverage was 87.3% among TB patients and 90.5% in the controls. No significant differences in B. Calmette-Guerin vaccination rates between the seronegative and seropositive children were seen. Coinfection with HIV and TB in children is now one of the major public health problems in Zambian children.
引用
收藏
页码:499 / 504
页数:6
相关论文
共 39 条
[21]   TUBERCULOSIS IN CHILDREN INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS - A REPORT OF 5 CASES [J].
MOSS, WJ ;
DEDYO, T ;
SUAREZ, M ;
NICHOLAS, SW ;
ABRAMS, E .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1992, 11 (02) :114-120
[22]  
MUGANGA N, 1991, PEDIATRIE, V46, P825
[23]  
NARAIN JR, IN PRESS TUBERCLE LU
[24]  
NEIMER RL, 1992, PEDIATR INFECT DIS J, V11, P114
[25]   PREVALENCE OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION AMONG PATIENTS ATTENDING TUBERCULOSIS CLINICS IN THE UNITED-STATES [J].
ONORATO, IM ;
MCCRAY, E .
JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (01) :87-92
[26]   INCREASED MORTALITY AND TUBERCULOSIS TREATMENT FAILURE RATE AMONG HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) SEROPOSITIVE COMPARED WITH HIV SERONEGATIVE PATIENTS WITH PULMONARY TUBERCULOSIS TREATED WITH STANDARD CHEMOTHERAPY IN KINSHASA, ZAIRE [J].
PERRIENS, JH ;
COLEBUNDERS, RL ;
KARAHUNGA, C ;
WILLAME, JC ;
JEUGMANS, J ;
KABOTO, M ;
MUKADI, Y ;
PAUWELS, P ;
RYDER, RW ;
PRIGNOT, J ;
PIOT, P .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (04) :750-755
[27]  
QUINN TC, 1989, REV INFECT DIS, V11, pS379
[28]  
Raviglione MC, 1992, B WORLD HEALTH ORGAN, V70, P512
[29]   TUBERCULOSIS IN DEVELOPING-COUNTRIES AND METHODS FOR ITS CONTROL [J].
RODRIGUES, LC ;
SMITH, PG .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (05) :739-744
[30]   TREATMENT OF TUBERCULOSIS IN PATIENTS WITH ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].
SMALL, PM ;
SCHECTER, GF ;
GOODMAN, PC ;
SANDE, MA ;
CHAISSON, RE ;
HOPEWELL, PC .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (05) :289-294