LYOTROPIC LIQUID-CRYSTALS AND THE STRUCTURAL LIPIDS OF THE STRATUM-CORNEUM

被引：12

作者：

KAYALI, I

SUHERY, T

FRIBERG, SE

SIMION, FA

RHEIN, LD

机构：

[1] CLARKSON UNIV,DEPT CHEM,POTSDAM,NY 13699

[2] COLGATE PALMOLIVE CO,RES & DEV,PISCATAWAY,NJ 08854

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 05期

关键词：

D O I：

10.1002/jps.2600800506

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipids were extracted from human stratum corneum and the remaining corneocytes were reaggregated with different lyotropic liquid crystals. Water transport through the reaggregated stratum corneum was determined using a diffusion chamber according to Smith and Blank. The permeability constant for the reaggregated stratum corneum with natural lipids was 25-40% lower than that with the surfactant liquid crystals, but there was no significant difference between different liquid crystals.

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页码：428 / 431

页数：4

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