IMIDAZOLE-ANALOGS OF 6-EPICASTANOSPERMINE AND OF 3,7A-DIEPIALEXINE

被引：42

作者：

FRANKOWSKI, A

SELIGA, C

BUR, D

STREITH, J

机构：

[1] UNIV HAUTE ALSACE,ECOLE NATL SUPER CHIM,3 RUE ALFRED WERNER,F-68093 MULHOUSE,FRANCE

[2] TECH UNIV LODZ,INST ORGAN CHEM,PL-90924 LODZ,POLAND

[3] UNIV BASEL,INST ANORGAN CHEM,CH-4056 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 05期

关键词：

D O I：

10.1002/hlca.19910740503

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral bicyclic imidazole derivatives 7 and 8 were obtained from D-glucose derivative 9 by a sequence of selective protection/deprotection and intramolecular S(N)2 reactions. Triols 7 and 8 are analogues of 6-epicastanospermine (4) and of 3,7a-diepialexine (6), respectively, and are potential glycosidase inhibitors. However, their anti-HIV activity proved to be only marginal.

引用

页码：934 / 940

页数：7