K-13 AND OF4949 - EVALUATION OF KEY PARTIAL STRUCTURES AND PHARMACOPHORE DELINEATION

被引：11

作者：

BOGER, DL

YOHANNES, D

机构：

[1] Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80885-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The angiotensin I converting enzyme and aminopeptidase B inhibitory properties of key analogs of K-13 and OF4949, constituting key partial structures or substructures of the natural products, are detailed in studies to define the essential pharmacophores.

引用

页码：245 / 250

页数：6

共 25 条

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[2] DESIGN AND SYNTHESIS OF A CONFORMATIONAL ANALOG OF DEOXYBOUVARDIN
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[3] STREPTONIGRIN AND LAVENDAMYCIN PARTIAL STRUCTURES - PROBES FOR THE MINIMUM, POTENT PHARMACOPHORE OF STREPTONIGRIN, LAVENDAMYCIN, AND SYNTHETIC QUINOLINE-5,8-DIONES
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BOGER, DL
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[5] SYNTHESIS OF N29-DESMETHYL RA-VII - IDENTIFICATION OF THE PHARMACOPHORE OF RA-I-VII AND DEOXYBOUVARDIN AND REASSIGNMENT OF THE SUBUNIT FUNCTIONAL ROLES
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[6] TOTAL SYNTHESIS OF DEOXYBOUVARDIN AND RA-VII - MACROCYCLIZATION VIA AN INTRAMOLECULAR ULLMANN REACTION
BOGER, DL
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[7] TOTAL SYNTHESIS OF L,L-ISODITYROSINE AND ISODITYROSINE-DERIVED AGENTS - K-13, OF4949-III, AND OF4949-IV
BOGER, DL
YOHANNES, D
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (24) : 6000 - 6017
[8] INTRAMOLECULAR ULLMANN CONDENSATION REACTION - AN EFFECTIVE APPROACH TO MACROCYCLIC DIARYL ETHERS
BOGER, DL
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (05) : 1763 - 1767
[9] EVALUATION OF BOUVARDIN, DEOXYBOUVARDIN, AND RA-I - RA-VII PARTIAL STRUCTURES - REASSIGNMENT OF THE PHARMACOPHORE
BOGER, DL
MYERS, JB
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SUNTORNWAT, O
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[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (06) : 313 - 316
[10] BOGER DL, 1991, SYNLETT, P33

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