NEAR-HAPLOID KARYOTYPE IN A SQUAMOUS-CELL LUNG-CARCINOMA

被引：14

作者：

DROUIN, V

VIGUIE, F

DEBESSE, B

机构：

[1] HOP HOTEL DIEU,BIOL FERTIL & CYTOGENET,1 PL PARVIS NOTRE DAME,F-75181 PARIS 04,FRANCE

[2] HOP LAENNEC,SERV CHIRURG THORAC,F-75340 PARIS 07,FRANCE

来源：

GENES CHROMOSOMES & CANCER | 1993年 / 7卷 / 04期

关键词：

D O I：

10.1002/gcc.2870070405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of a squamous cell lung carcinoma revealed a near-haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes. (C) 1993 Wile Liss, Inc.

引用

页码：209 / 212

页数：4

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