A POSITIVE CORRELATION BETWEEN THE PRECURSOR FREQUENCY OF CYTOTOXIC LYMPHOCYTES TO AUTOLOGOUS EPSTEIN-BARR VIRUS-TRANSFORMED B-CELLS AND ANTIBODY TITER LEVEL AGAINST EPSTEIN-BARR VIRUS-ASSOCIATED NUCLEAR ANTIGEN IN HEALTHY SEROPOSITIVE INDIVIDUALS

被引：23

作者：

KUSUNOKI, Y

HUANG, H

FUKUDA, Y

OZAKI, K

SAITO, M

HIRAI, Y

AKIYAMA, M

机构：

[1] RADIAT EFFECTS RES FDN,DEPT RADIOBIOL,5-2 HIJIYAMA PK,MINAMI KU,HIROSHIMA 732,JAPAN

[2] UNIV WISCONSIN,DEPT ZOOL,DEV BIOL LAB,MADISON,WI 53706

[3] CHILDRENS HOSP MED CTR NO CALIF,OAKLAND,CA 94609

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 37卷 / 06期

关键词：

EPSTEIN-BARR VIRUS; LIMITING DILUTION ASSAY; SPECIFIC KILLER T-CELLS; ANTIBODY TITER;

D O I：

10.1111/j.1348-0421.1993.tb03237.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A limiting dilution analysis was established to determine the precursor frequency (PF) of cytotoxic lymphocytes against autologous B cells transformed with the Epstein-Barr virus (EBV). This method was found to detect mainly self-restricted T-cell activity and little non-self-restricted cytotoxicity. The mean PF in 21 healthy EBV-seropositive persons was 1.4 x 10(-3) (range : 0.03 x 10(-3) to 8.7 X 10(-3)) for peripheral blood mononuclear cells, whereas 4 samples of mononuclear cells obtained from umbilical cord blood had PFs below 0.007 x 10(-3). A positive correlation was observed between the PF and serum antibody titers against EBV-associated nuclear antigen among the seropositive persons.

引用

页码：461 / 469

页数：9

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