SYN AND ANTI-ORIENTED IMIDAZOLE CARBOXYLATES AS MODELS FOR THE HISTIDINE-ASPARTATE COUPLE IN SERINE PROTEASES AND OTHER ENZYMES

被引：38

作者：

ZIMMERMAN, SC

KORTHALS, JS

CRAMER, KD

机构：

[1] Department of Chemistry, University of Illinois, Urbana

来源：

TETRAHEDRON | 1991年 / 47卷 / 14-15期

关键词：

D O I：

10.1016/S0040-4020(01)81797-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several compounds containing an imidazole and a carboxylic acid group have been synthesized and studied as models for the His-Asp couple found in serine proteases and other enzymes. The ability of the carboxylic acid group to increase the basicity of the imidazole and its role in nucleophilic and general base catalysis by the imidazole is described.

引用

页码：2649 / 2660

页数：12

共 59 条

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