PRIMARY STRUCTURE OF RAT PANCREATIC LIPASE MESSENGER-RNA

被引：37

作者：

WICKERPLANQUART, C

PUIGSERVER, A

机构：

[1] Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, F-13 402 Marseille Cedex 9

来源：

FEBS LETTERS | 1992年 / 296卷 / 01期

关键词：

RAT PANCREAS LIPASE; NUCLEOTIDE SEQUENCE;

D O I：

10.1016/0014-5793(92)80403-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of a rat pancreatic lipase mRNA was determined. The data have been assigned the following accession number, X61925, in the EMBL data library. The total length of the messenger is 1531 nucleotides, plus a poly(A) stretch of about 60 nucleotides. A 72-nucleotides 5'-noncoding region is followed by a 1419-nucleotides open reading frame which encodes a protein of 473 amino acids, including the 17 amino acid signal peptide. The mature enzyme (456 residues) has 6 additional C-terminal amino acids, as compared with the amino acid sequence of pig (direct amino acid sequence), dog, man and rat isoenzyme from Genbank, M58369 (all deduced from the nucleotide sequence). A higher degree of homology exists between the amino acid sequence of rat mature enzyme with those of dog (88%), pig (75%) and man (75%) than with that of rat isolipase (74%).

引用

页码：61 / 66

页数：6

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