THE RNA-POLYMERASE-II HOLOENZYME AND ITS IMPLICATIONS FOR GENE-REGULATION

被引：277

作者：

KOLESKE, AJ ^{[1
]}

YOUNG, RA ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(00)88977-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RNA polymerase II (Pol II) transcription initiation apparatus consists of several multisubunit complexes, including Pol II, general transcription factors and suppressor of RNA polymerase B (SRB) proteins. Recent evidence indicates that many of these components assemble into a large complex, called the RNA polymerase holoenzyme, the SRB components of which participate in the response to transcriptional regulators. We discuss these results and their implications for the regulation of gene expression.

引用

页码：113 / 116

页数：4

共 46 条

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