ELECTROCHEMICAL STUDY OF IPRONIAZID AND ITS ANALYTICAL DETERMINATION BY DIFFERENTIAL-PULSE POLAROGRAPHY

被引：3

作者：

MARTIN, ME ^{[1
]}

BORGES, TM ^{[1
]}

ARIAS, JJ ^{[1
]}

GONZALEZ, S ^{[1
]}

机构：

[1] UNIV LA LAGUNA,DEPT QUIM FIS,E-38204 LA LAGUNA,SPAIN

来源：

ELECTROANALYSIS | 1994年 / 6卷 / 5-6期

关键词：

IPRONIAZID; DIFFERENTIAL PULSE POLAROGRAPHY;

D O I：

10.1002/elan.1140060522

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Iproniazid was found to be irreversibly reduced in two steps, involving the exchange of two electrons and two protons each, by using tast polarography, normal pulse polarography, (NPP), and cyclic voltammetry (CV). The rate constants of these two steps were found to be 5.8 x 10(-6) and 4.2 X 10(-6) and 4.2 x 10(-6) cm s-1, respectively, and their corresponding diffusion coefficients 4.5 x 10(-6) and 8.3 x 10(-5) cm2 s-1. Also, alpha, the coefficient of cathodic transfer, was found to be 0.20 to 0.25 for the first peak and 0.17 to 0.15 for the second. On the basis of the electrochemical study performed, a differential pulse polarographic method for the determination of iproniazid over the concentration range of 5 x 10(-7) M to 1 X 10(-4) M was developed.

引用

页码：491 / 496

页数：6

共 15 条

[11] THEORY OF STATIONARY ELECTRODE POLAROGRAPHY - SINGLE SCAN + CYCLIC METHODS APPLIED TO REVERSIBLE IRREVERSIBLE + KINETIC SYSTEMS [J].