KINETICS OF PLASMA CORTICOSTEROIDS DURING METYRAPONE INFUSION IN MAN

被引：5

作者：

LEJEUNELENAIN, C ^{[1
]}

WOLTER, R ^{[1
]}

FRANCKSON, JRM ^{[1
]}

机构：

[1] HOP UNIV ST PIERRE,DEPT PAEDIAT,B-1000 BRUSSELS,BELGIUM

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 04期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb02087.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of metyrapone on plasma kinetics of cortisol (F), 11‐deoxycortisol (S), corticosterone (B), 11‐deoxycorticosterone (DOC), aldosterone (Aldo) and 17 hydroxyprogesterone (17 OHP) was studied in ten normal prepubertal children intravenously infused with the drug (1 gm/1.73 m2 body surface area in 4 h). Similar falls in F, B and Aldo were observed during the first hour expressing similar sensitivity of the 11 hydroxylases to the drug. The effect of the compensatory increase of endogenous ACTH could be detected after 1 hour by the rise in 17 OHP. However the concentrations of the 11‐hydroxy compounds, F, B and Aldo, remained low throughout the infusion period. From the second hour onwards, facilitation of the synthesis of DOC was noticed. After the end of infusion, the levels of the precursors decreased and F and B were restored to initial values. Aldo remained low probably due to the inhibitory effect of the elevated DOC on the renin‐angiotensin system. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：319 / 328

页数：10

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