SUBTHALAMIC NUCLEOTOMY ALLEVIATES PARKINSONISM IN THE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-EXPOSED PRIMATE

被引：107

作者：

AZIZ, TZ

PEGGS, D

AGARWAL, E

SAMBROOK, MA

CROSSMAN, AR

机构：

[1] Experimental Neurology and Myology Group, Department of Cell and Structural Biology, The Medical School, Manchester, M13 9PT, Oxford Road

来源：

BRITISH JOURNAL OF NEUROSURGERY | 1992年 / 6卷 / 06期

基金：

英国医学研究理事会;

关键词：

LESIONS; MPTP; PARKINSONISM; SUBTHALAMIC NUCLEUS;

D O I：

10.3109/02688699209002375

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Research into the neural mechanisms underlying the symptoms of parkinsonism utilizing the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate model have shown that the subthalamic nucleus (STN) occupies a central role. As a logical development of this theory, we have studied the effects of thermocoagulative lesions of the STN in the primate model. Such lesions can cause remarkable symptom reversal in the experimental primate model.

引用

页码：575 / 582

页数：8

共 37 条

[31] THE ROLE OF STRIATOPALLIDAL NEURONS UTILIZING GAMMA-AMINOBUTYRIC-ACID IN THE PATHOPHYSIOLOGY OF MPTP-INDUCED PARKINSONISM IN THE PRIMATE - EVIDENCE FROM [H-3] FLUNITRAZEPAM AUTORADIOGRAPHY
ROBERTSON, RG
CLARKE, CA
BOYCE, S
SAMBROOK, MA
CROSSMAN, AR
[J]. BRAIN RESEARCH, 1990, 531 (1-2) : 95 - 104
[32] ROBERTSON RG, 1990, NEUROSCI LETT S, V38, pS13
[33] SHANTHA TR, 1968, STEREOTACTIC ATLAS J
[34] CAMPOTOMY IN VARIOUS EXTRAPYRAMIDAL DISORDERS
SPIEGEL, EA
BAIRD, HW
SZEKELY, EG
FLANAGAN, M
WYCIS, HT
ADAMS, J
[J]. JOURNAL OF NEUROSURGERY, 1963, 20 (10) : 871 - &
[35] PROJECTIONS OF CHOLINERGIC AND NON-CHOLINERGIC NEURONS OF THE BRAIN-STEM CORE TO RELAY AND ASSOCIATIONAL THALAMIC NUCLEI IN THE CAT AND MACAQUE MONKEY
STERIADE, M
PARE, D
PARENT, A
SMITH, Y
[J]. NEUROSCIENCE, 1988, 25 (01) : 47 - 67
[36] TREATMENT OF PARKINSONISM BY STEREOTACTIC THERMOLESIONS IN THE PALLIDAL REGION - A CLINICAL-EVALUATION OF 81 CASES
SVENNILSON, E
TORVIK, A
LOWE, R
LEKSELL, L
[J]. ACTA PSYCHIATRICA ET NEUROLOGICA, 1960, 35 (03): : 358 - 377
[37] ZWIEG RM, 1989, ANN NEUROL, V26, P41

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