HUMAN ISLET AMYLOID POLYPEPTIDE TRANSGENIC MICE AS A MODEL OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM)

被引:76
作者
FOX, N
SCHREMENTI, J
NISHI, M
OHAGI, S
CHAN, SJ
HEISSERMAN, JA
WESTERMARK, GT
LECKSTROM, A
WESTERMARK, P
STEINER, DF
机构
[1] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637
[2] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
[3] LINKOPING UNIV,DEPT PATHOL,S-58183 LINKOPING,SWEDEN
关键词
TRANSGENIC MOUSE; ISLET AMYLOID POLYPEPTIDE; AMYLIN; NON-INSULIN-DEPENDENT DIABETES-MELLITUS; ISLET AMYLOID; ISLET OF LANGERHANS;
D O I
10.1016/0014-5793(93)81444-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To model islet amyloidogenesis in NIDDM and explore the glucoregulatory role of islet amyloid polypeptide (IAPP), we have created transgenic mice containing a rat insulin-I promoter-human IAPP fusion gene. Expression of human IAPP was localized to the islets of Langerhans, anterior pituitary and brain in transgenic animals; blood IAPP levels were elevated 5-fold while fasting glucose levels remained normal. Amyloid deposits have not been detected in transgenic islets suggesting that other co-existing abnormalitites in NIDDM may be required for the formation of islet amyloid. These animals provide a unique model for exploring this hypothesis and other proposed functions of IAPP.
引用
收藏
页码:40 / 44
页数:5
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