THE EFFECT OF BONE-MARROW AND THYMUS CHIMERISM BETWEEN NONOBESE DIABETIC (NOD) AND NOD-E TRANSGENIC MICE, ON THE EXPRESSION AND PREVENTION OF DIABETES

被引：38

作者：

PARISH, NM ^{[1
]}

CHANDLER, P ^{[1
]}

QUARTEYPAPAFIO, R ^{[1
]}

SIMPSON, E ^{[1
]}

COOKE, A ^{[1
]}

机构：

[1] CRC,HARROW,ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 10期

关键词：

NOD MICE; DIABETES; CLASS-II ANTIGEN; CHIMERAS;

D O I：

10.1002/eji.1830231042

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The non-obese diabetic (NOD) mouse is an established animal model of the autoimmune disease, insulin-dependent diabetes mellitus (IDDM). The NOD-E mouse is a transgenic mouse which expresses the I-E molecule (absent in NOD mice). Expression of I-E protects these mice from both insulitis and IDDM. We have investigated the possible mechanisms of this protection by constructing bone marrow, and combined bone marrow and thymus chimeras between NOD and NOD-E mice. Our data suggest that thymic epithelium may play no direct role in either protection against, or promotion of, IDDM. Protection from diabetes is provided either by NOD-E donor bone marrow or NOD-E recipient non-thymic radio-resistant cells. The means by which protection may be achieved in this system are discussed.

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收藏

页码：2667 / 2675

页数：9

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