PHOTOCONTACT DERMATITIS DUE TO 4-CHLORO-2-HYDROXYBENZOIC-ACID-N-BUTYL-AMIDE .2. PHOTOCHEMICAL INVESTIGATIONS

In the photoallergy to an antimycotic agent for topical use, 4-chloro-2-hydroxybenzoic-acid-n-butylamine (Jadit®), the photochemical mechanism of antigen formation is investigated. Applied on the surface of skin the substance acts as a UV C protector. By irradiation in alkaline solutions a photochemical degradation occurs in various steps. The first step is suggested to be a splitting off of chlorine leading to the formation of free radicals. In further steps a recombination of those radicals into dimere products is observed. In contact with the skin or serum albumine these light induced free radicals are directly attached to protein to form a complete antigen. © 1968 Springer-Verlag.