INVERTEBRATE PHARMACOLOGICAL ASSAY OF NOVEL, POTENT GLUTAMATE RECEPTOR ANTAGONISTS - ACYLATED SPERMINES

被引:19
作者
BLAGBROUGH, IS
BRUCE, M
BYCROFT, BW
MATHER, AJ
USHERWOOD, PNR
机构
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND
[2] UNIV NOTTINGHAM,DEPT ZOOL,NOTTINGHAM NG7 2RD,ENGLAND
来源
PESTICIDE SCIENCE | 1990年 / 30卷 / 04期
关键词
D O I
10.1002/ps.2780300404
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
Synthetic analogues of arthropod polyamine-containing toxins have been investigated for antagonism of the quisqualate-sensitive L-glutamate receptor (quis-GluR) of locust muscle. Block of the cation-selective channel gated by quis-GluR was demonstrated for N-(4-hydroxyphenylpropanoyl)-and N-(4-hydroxyphenylacetyl)-spermine at significantly lower concentrations than that for spermine.
引用
收藏
页码:397 / 403
页数:7
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