INVERTEBRATE PHARMACOLOGICAL ASSAY OF NOVEL, POTENT GLUTAMATE RECEPTOR ANTAGONISTS - ACYLATED SPERMINES

被引：19

作者：

BLAGBROUGH, IS

BRUCE, M

BYCROFT, BW

MATHER, AJ

USHERWOOD, PNR

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] UNIV NOTTINGHAM,DEPT ZOOL,NOTTINGHAM NG7 2RD,ENGLAND

来源：

PESTICIDE SCIENCE | 1990年 / 30卷 / 04期

关键词：

D O I：

10.1002/ps.2780300404

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Synthetic analogues of arthropod polyamine-containing toxins have been investigated for antagonism of the quisqualate-sensitive L-glutamate receptor (quis-GluR) of locust muscle. Block of the cation-selective channel gated by quis-GluR was demonstrated for N-(4-hydroxyphenylpropanoyl)-and N-(4-hydroxyphenylacetyl)-spermine at significantly lower concentrations than that for spermine.

引用

页码：397 / 403

页数：7

共 16 条

[1] POSTSYNAPTIC BLOCK OF A GLUTAMATERGIC SYNAPSE BY LOW-MOLECULAR WEIGHT FRACTIONS OF SPIDER VENOM
BATEMAN, A
BODEN, P
DELL, A
DUCE, IR
QUICKE, DLJ
USHERWOOD, PNR
[J]. BRAIN RESEARCH, 1985, 339 (02) : 237 - 244
[2] INVERTEBRATE PHARMACOLOGICAL ASSAY OF NOVEL, POTENT GLUTAMATE RECEPTOR ANTAGONISTS - ACYLATED SPERMINES
BLAGBROUGH, IS
BRUCE, M
BYCROFT, BW
MATHER, AJ
USHERWOOD, PNR
[J]. PESTICIDE SCIENCE, 1990, 30 (04): : 397 - 403
[3] BLAGBROUGH IS, 1989, J PHARM PHARM SUPPL, V41
[4] BRUCE M, 1990, IN PRESS TOXICON
[5] RELATIVE TROPHIC INFLUENCES OF EXCITATORY AND INHIBITORY INNERVATION OF LOCUST SKELETAL-MUSCLE FIBERS
CLARK, RB
GRATION, KAF
USHERWOOD, PNR
[J]. NATURE, 1979, 280 (5724) : 679 - 682
[6] STRUCTURE AND SYNTHESIS OF A POTENT GLUTAMATE RECEPTOR ANTAGONIST IN WASP VENOM
ELDEFRAWI, AT
ELDEFRAWI, ME
KONNO, K
MANSOUR, NA
NAKANISHI, K
OLTZ, E
USHERWOOD, PNR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) : 4910 - 4913
[7] SPIDER TOXINS AS TOOLS FOR DISSECTING ELEMENTS OF EXCITATORY AMINO-ACID TRANSMISSION
JACKSON, H
USHERWOOD, PNR
[J]. TRENDS IN NEUROSCIENCES, 1988, 11 (06) : 278 - 283
[8] PIEK T, 1985, COMPREHENSIVE INSECT, V11, P55
[9] USHERWOOD PN, 1968, J EXP BIOL, V49, P341
[10] USHERWOOD PN, 1967, AM ZOOL, V7, P553

← 1 2 →