FEEDBACK INHIBITION BY CALCIUM LIMITS THE RELEASE OF CALCIUM BY INOSITOL TRISPHOSPHATE IN LIMULUS VENTRAL PHOTORECEPTORS

被引：100

作者：

PAYNE, R

FLORES, TM

FEIN, A

机构：

[1] UNIV MARYLAND,DEPT BIOCHEM,COLLEGE PK,MD 20742

[2] UNIV CONNECTICUT,CTR HLTH,DEPT PHYSIOL,FARMINGTON,CT 06032

来源：

NEURON | 1990年 / 4卷 / 04期

关键词：

D O I：

10.1016/0896-6273(90)90112-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from this inhibition has a half-time of between 1.5 and 5 s at 20°C. Calcium released by (InsP3) therefore inhibits further release of calcium from InsP3-sensitive calcium stores. This feedback inhibition may protect the calcium stores from depletion during prolonged bright illumination. Feedback inhibition, rather than periodic depletion of calcium stores, may also underlie the oscillatory bursts of InsP3-induced calcium release that have been observed in many cell types. © 1990.

引用

页码：547 / 555

页数：9

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