HYPOGLYCEMIA AND DIABETES-MELLITUS FOLLOWING PARENTERAL PENTAMIDINE MESYLATE TREATMENT IN AIDS PATIENTS

被引：25

作者：

PERRONNE, C ^{[1
]}

BRICAIRE, F ^{[1
]}

LEPORT, C ^{[1
]}

ASSAN, D ^{[1
]}

VILDE, JL ^{[1
]}

ASSAN, R ^{[1
]}

机构：

[1] HOP BICHAT,DEPT DIABET,46 RUE HENRI HUCHARD,F-75877 PARIS 18,FRANCE

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 07期

关键词：

AIDS; Drug‐induced diabetes; Drug‐induced hypoglycaemia; Hypoglycaemia; Pentamidine;

D O I：

10.1111/j.1464-5491.1990.tb01453.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Of 18 AIDS patients with Pneumocystis carinii pneumonia treated with pentamidine mesylate parenterally, four developed serious to severe hypoglycaemia, three hypoglycaemia followed by insulin‐requiring diabetes, and two others diabetes alone. Hypoglycaemia (blood glucose 2.1 ± 0.2 (±SE) mmol l−1) occurred 9 (2–22) days after starting treatment, and diabetes (initial blood glucose 30 ± 6 mmol l−1) after 60 (20–90) days. The other patients remained euglycaemic. The dysglycaemic patients (hypo‐ and hyper‐glycaemic) had a higher pentamidine dosage (p < 0.01), and higher serum creatinine levels at end of treatment (p < 0.001), consistent with drug accumulation and dose‐dependent toxicity. Plasma C‐peptide levels were low in the diabetic patients, in the basal state (0.25–0.28 nmol l−1) and following stimulation by IV glucagon (0.35–0.40 nmol l−1), vs 0.80 ± 0.06 nmol l−1 (basal) and 1.83 ± 0.16 nmol l−1 (stimulated) in 23 healthy control subjects (mean ± SE). Islet cell or insulin antibodies were not detected. Serum amylase levels rose abnormally in the dysglycaemic group, and pancreatitis was proved in one, and suspected in another patient. None of 28 similar AIDS patients whose P. carinii pneumonia was treated with cotrimoxazole showed blood glucose disturbance. 1990 Diabetes UK

引用

页码：585 / 589

页数：5

共 48 条

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