IDENTIFICATION OF AN EMBRYONIC ISOFORM OF MYELIN BASIC-PROTEIN THAT IS EXPRESSED WIDELY IN THE MOUSE EMBRYO

被引：104

作者：

MATHISEN, PM

PEASE, S

GARVEY, J

HOOD, L

READHEAD, C

机构：

[1] Molecular Biotechnology Department, School of Medicine, University of Washington, Seattle

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 21期

关键词：

DEVELOPMENT; GENE EXPRESSION; REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION;

D O I：

10.1073/pnas.90.21.10125

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon up-stream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, the thymus, spleen, and testes also express E-MBP at the protein level. The expression of E-MBP in cell types distinct from the nervous system strongly suggests that this MBP isoform has a role apart from the formation of myelin.

引用

页码：10125 / 10129

页数：5

共 26 条

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