INTRACEREBROVENTRICULAR ANGIOTENSIN II-INDUCED THIRST AND SODIUM APPETITE IN RAT ARE BLOCKED BY THE AT1 RECEPTOR ANTAGONIST, LOSARTAN (DUP-753), BUT NOT BY THE AT(2) ANTAGONIST, CGP-42112B

In the rat, intakes of water and 1.8 % NaCl induced by I.C.V. angiotensin II were inhibited by prior I.C.V. injection of the angiotensin subtype 1 receptor antagonist, Losartan, but not by the subtype 2 receptor antagonist, CGP 42112B. Drinking induced by i.c.v. carbachol was unaffected by either antagonist.