ALLERGENICITY OF ROSIN (COLOPHONY) ESTERS .2. GLYCERYL MONOABIETATE IDENTIFIED AS CONTACT ALLERGEN

In the esterification of rosin with glycerol, the main compound formed, glyceryl triabietate, shows low allergenic activity. In this study, compounds formed in smaller amounts, when abietic acid (main component in rosin) was esterified with glycerol, were identified as glyceryl-1-monoabietate (GMA), glyceryl-1,2-diabietate (GDA1,2) and glyceryl-1,3-diabietate (GDA1,3), using nuclear magnetic resonance (NMR), infra-red (IR) and mass spectrometry (MS) analyses. According to animal experiments, GMA was a contact allergen. No cross-reactivity was seen to allergens in unmodified rosin. Some patients allergic to unmodified rosin reacted when tested with GMA. No reactions were seen to the 2 diabietates. Some patients also reacted to commercial glycerol-modified rosins. GMA together with unmodified abietic acid were identified in these rosin samples. The reactions seen in rosin-sensitive patients to commercial glycerol-esterified rosins probably derive from the unmodified material still present in the product, but could also be the result of GMA obtained from the glycerol derivatization.