HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF DOXACURIUM, A NEW LONG-ACTING NEUROMUSCULAR BLOCKER

被引：14

作者：

DEANGELIS, R ^{[1
]}

LOEBS, P ^{[1
]}

MAEHR, R ^{[1
]}

SAVARESE, J ^{[1
]}

WELCH, R ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,NEW YORK HOSP,SCH MED,DEPT ANESTHESIOL,NEW YORK,NY 10021

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 525卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)83415-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid and sensitive high-performance liquid chromatographic procedure was developed for the analysis of the new, long-acting neuromuscular blocker doxacurium in the plasma and urine of dog and man and in the bile of dog. Samples were prepared on solid-phase extraction cartridges containing a methyl (C1) bonded phase and were chromatographed on a 15 cm reversed-phase column (C1) using a mobile phase of 0.05 M monobasic potassium phosphate-acetonitrile (30:70, v/v). The compound was detected at 210 nm with a lower limit of quantitation of 10 ng/ml. An inter-assay accuracy of 90-92% was obtained for the analysis of the drug from biological fluids. The method was applied to studies of doxacurium after intravenous administration to dog and man. © 1990.

引用

页码：389 / 400

页数：12

共 18 条

[11]

Reynolds D L, 1983, J Pharm Biomed Anal, V1, P347, DOI 10.1016/0731-7085(83)80047-8

[12] THE CLINICAL NEUROMUSCULAR PHARMACOLOGY OF MIVACURIUM CHLORIDE (BW B1090U) - A SHORT-ACTING NONDEPOLARIZING ESTER NEUROMUSCULAR BLOCKING DRUG [J].

SAVARESE, JJ ;

ALI, HH ;

BASTA, SJ ;

EMBREE, PB ;

SCOTT, RPF ;

SUNDER, N ;

WEAKLY, JN ;

WASTILA, WB ;

ELSAYAD, HA .

ANESTHESIOLOGY, 1988, 68 (05) :723-732

[13]

SAVARESE JJ, 1983, ANESTHESIOLOGY, V59, pA274

[14] PHARMACOKINETICS OF THE NONDEPOLARIZING NEUROMUSCULAR RELAXANTS APPLIED TO CALCULATION OF BOLUS AND INFUSION DOSAGE REGIMENS [J].

SHANKS, CA .

ANESTHESIOLOGY, 1986, 64 (01) :72-86

[15] DETERMINATION OF ATRACURIUM, LAUDANOSINE AND RELATED-COMPOUNDS IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

SIMMONDS, RJ .

JOURNAL OF CHROMATOGRAPHY, 1985, 343 (02) :431-436

[16]

STILLER RL, 1985, ANESTH ANALG, V64, P58

[17]

WEATHERLEY BC, 1983, BRIT J ANAESTH, V55, pS39

[18] CLINICAL-SIGNIFICANCE OF ESTERASES IN MAN [J].

WILLIAMS, FM .

CLINICAL PHARMACOKINETICS, 1985, 10 (05) :392-403

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