CONTROL OF THYROGLOBULIN SYNTHESIS AND SECRETION .1.

被引：255

作者：

VANHERLE, AJ

VASSART, G

DUMONT, JE

机构：

[1] FREE UNIV BRUSSELS, FAC MED, INST INTERDISCIPLINARY RES, B-1050 BRUSSELS, BELGIUM

[2] EURATOM, DEPT BIOL, B-1000 BRUSSELS, BELGIUM

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1979年 / 301卷 / 05期

关键词：

D O I：

10.1056/NEJM197908023010504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

(First of Two Parts) THE thyroid has two main endocrine functions: secretion of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) by the follicular cells and secretion of calcitonin by the C cells. Thyroid hormones are first synthesized as a prohormone, thyroglobulin, which is a large glycoprotein. This prohormone is also released by the thyroid and constitutes a normal plasma component. This article reviews recent developments in the synthesis, secretion and control of thyroglobulin. Wherever possible, we discuss data on the human thyroid gland and the clinical aspects of thyroglobulin secretion. Physiologic Features or the Thyroid. © 1979, Massachusetts Medical Society. All rights reserved.

引用

页码：239 / 249

页数：11

共 153 条

[51] EFFECT OF TSH ON IODINE-METABOLISM AND INTERMEDIARY METABOLISM IN TISSUE FROM PATIENTS WITH GRAVES-DISEASE [J].