BEHAVIORAL AND BIOCHEMICAL EFFECTS OF AN ICV INJECTION OF STREPTOZOTOCIN IN OLD LEWIS RATS

被引：41

作者：

BLOKLAND, A ^{[1
]}

JOLLES, J ^{[1
]}

机构：

[1] UNIV LIMBURG,DEPT NEUROPSYCHOL & PSYCHOBIOL,6200 MD MAASTRICHT,NETHERLANDS

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 04期

关键词：

ANIMAL MODEL; STREPTOZOTOCIN; GLUCOSE METABOLISM; CHOLINE ACETYLTRANSFERASE ACTIVITY; HIPPOCAMPUS; ALZHEIMERS DISEASE; LEARNING;

D O I：

10.1016/0091-3057(94)90284-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Intracerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggest also that susceptibility to STREP may not be related to age in Lewis rats.

引用

页码：833 / 837

页数：5

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