PRODUCTION OF INTERLEUKIN-1 (IL-1) AND IL-1 INHIBITOR BY HUMAN MONOCYTES EXPOSED TO DENGUE VIRUS

被引:38
作者
CHANG, DM [1 ]
SHAIO, MF [1 ]
机构
[1] NATL DEF MED CTR,DEPT PARASITOL & TROP MED,TAIPEI,TAIWAN
关键词
D O I
10.1093/infdis/170.4.811
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dengue hemorrhagic fever-dengue shock syndrome, the most severe manifestation of an acute dengue virus (DV) infection, is endemic in Southeast Asia. Antibody-dependent enhancement of DV growth in mononuclear phagocytes is thought to be the mechanism whereby preexisting dengue antibodies confer excess risk for this outcome. Interleukin-1 (IL-1) may play an important role in the pathogenetic mechanisms that cause dengue fever and shock. It was shown that both IL-1 and tumor necrosis factor-alpha are secreted from monocytes within 4 h after DV infection. However, there was no increase in IL-1 secretion by virus-stimulated monocytes from dengue fever patients compared with healthy controls. Significant amounts of IL-1 were secreted by DV-infected monocytes in the presence of aggregated immunoglobulin or immune complexes, In addition, a new 600-kDa IL-1 inhibitor from the supernatants of DV-infected monocytes was identified. This inhibitor may cause immunosuppression and influence the process of DV infection.
引用
收藏
页码:811 / 817
页数:7
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