TRADITIONAL MEDICINAL-PLANTS OF THAILAND .22. CYTOTOXIC AND ANTIMALARIAL ALKALOIDS FROM THE BULBS OF CRINUM-AMABILE

被引:171
作者
LIKHITWITAYAWUID, K
ANGERHOFER, CK
CHAI, HB
PEZZUTO, JM
CORDELL, GA
机构
[1] UNIV ILLINOIS, COLL PHARM, DEPT MED CHEM & PHARMACOGNOSY, PROGRAM COLLABORAT RES PHARMACEUT SCI, CHICAGO, IL 60612 USA
[2] CHULALONGKORN UNIV, FAC PHARMACEUT SCI, DEPT PHARMACOGNOSY, BANGKOK 5, THAILAND
来源
JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 08期
关键词
D O I
10.1021/np50098a017
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
From the bulbs of Crinum amabile (Amaryllidaceae), a new alkaloid (-)-amabiline [1], together with the known alkaloids (-)-lycorine [2], (-)-buphanisine [3], (-)-augustine [4], and (+)-crinamine [5], were isolated. The structural characterization of 1 and the revised H-1- and C-13-nmr assignments of 2 are discussed. Alkaloids 2, 4, and 5 were found to be the principal cytotoxic and antimalarial constituents.
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页码:1331 / 1338
页数:8
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