INTRAARTICULAR CORTICOSTEROIDS FOR CHRONIC ARTHRITIS IN CHILDREN - EFFICACY AND EFFECTS ON CARTILAGE AND GROWTH

被引：106

作者：

HUPPERTZ, HI ^{[1
]}

TSCHAMMLER, A ^{[1
]}

HORWITZ, AE ^{[1
]}

SCHWAB, KO ^{[1
]}

机构：

[1] UNIV WURZBURG, INST DIAGNOST RADIOL, W-8700 WURZBURG, GERMANY

来源：

JOURNAL OF PEDIATRICS | 1995年 / 127卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(95)70320-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives: To assess the efficacy and effects on cartilage and statural growth of intraarticular corticosteroid (IAS) therapy for chronic arthritis in children and adolescents. Methods: We examined 21 children and adolescents with chronic arthritis (median duration, 8 months) that did not respond to nonsteroidal antiinflammatory drugs. The 21 joints injected with triamcinolone-hexacetonide were examined before and 7 weeks after IAS therapy by gadolinium-enhanced magnetic resonance imaging; 14 joints were also examined 13 months after IAS therapy. Results: All joints treated with IAS had improvement. Magnetic resonance imaging showed long-lasting suppression of inflammation and pannus without evidence of toxic effects on cartilage. Statural growth was not affected. Conclusion: In experienced hands, IAS therapy may be a safe and effective tool in the treatment of chronic arthritis in childhood. Long-term follow-up is mandatory.

引用

页码：317 / 321

页数：5

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