FLUPIRTINE PROTECTS AGAINST ISCHEMIC RETINAL DYSFUNCTION IN RATS

被引：28

作者：

BLOCK, F

PERGANDE, G

SCHWARZ, M

机构：

[1] UNIV ESSEN GESAMTHSCH, DEPT NEUROL, D-45147 ESSEN, GERMANY

[2] GERMANY ASTA MED AG, DEPT MED, D-60314 FRANKFURT, GERMANY

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

RETINAL ISCHEMIA; FLUPIRTINE; ELECTRORETINOGRAM; RAT;

D O I：

10.1097/00001756-199412000-00056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE present study investigated whether flupirtine attenuates the depression and enhances the recovery of the b-wave of the electroretinogram (ERG) in response to retinal ischaemia. The ERG was recorded from pentobarbital-anaesthetized rats before, during and after transient (24 min) occlusion of both common carotid arteries. Flupirtine administered 20 min before ischaemia reduced the depression of the b-wave during occlusion and accelerated recovery during reperfusion. When given at the onset of ischaemia flupirtine led to attenuation of the reduction of the b-wave during occlusion and to enhancement of the recovery during reperfusion. The present results suggest that flupirtine provides protection against ischaemic retinal dysfunction.

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页码：2630 / 2632

页数：3

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