OCTAMER-BINDING PROTEINS IN DIVERSE HEMATOPOIETIC-CELLS

被引：41

作者：

COCKERILL, PN

KLINKEN, SP

机构：

[1] Institute of Medical Research, Royal Melbourne Hospital, Melbourne

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 03期

关键词：

D O I：

10.1128/MCB.10.3.1293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which binds the octamer element (ATTTGCAT). We have further examined the role of this octamer element in directing the lymphoic-specific expression of the immunoglobulin H enhancer. No direct relationship was found between the levels of expression of the Cμ gene and oct-2. Indeed, variable amounts of oct-2 were detected in all of the hemopoietic lineage cells tested in this study.

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页码：1293 / 1296

页数：4

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