INTERMOLECULAR RADICAL C-C BOND FORMATION - SYNTHESIS OF A NOVEL DINUCLEOSIDE LINKER FOR NON-ANIONIC ANTISENSE OLIGONUCLEOSIDES

被引：21

作者：

DEBART, F ^{[1
]}

VASSEUR, JJ ^{[1
]}

SANGHVI, YS ^{[1
]}

COOK, PD ^{[1
]}

机构：

[1] ISIS PHARMACEUT, 2280 FARADAY AVE, CARLSBAD, CA 92008 USA

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 19期

关键词：

ANTISENSE OLIGONUCLEOTIDES; NONIONIC BACKBONE; INTERMOLECULAR RADICAL REACTION;

D O I：

10.1016/S0040-4039(00)79047-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.

引用

页码：2645 / 2648

页数：4

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