SYNTHESIS OF 3'-DEOXY-3'-(2-PROPYNYL)THYMIDINE AND 3'-CYANOMETHYL-3'-DEOXYTHYMIDINE, ANALOGS OF AZT

被引:60
作者
FIANDOR, J [1 ]
TAM, SY [1 ]
机构
[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,NUTLEY,NJ 07110
关键词
D O I
10.1016/S0040-4039(00)94577-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient procedure using free radical chemistry for introducing a carbon substituent to the 3′-position of 3′-deoxythymidine is described. An application of this procedure to the synthesis of 3′-deoxy-3′-(2-propynyl)thymidine and 3′-cyanomethyl-3′-deoxythymidine, two close analogs of AZT, is presented. © 1990.
引用
收藏
页码:597 / 600
页数:4
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