AZIDOTHYMIDINE - CRYSTAL-STRUCTURE AND POSSIBLE FUNCTIONAL-ROLE OF THE AZIDO GROUP

被引：86

作者：

CAMERMAN, A

MASTROPAOLO, D

CAMERMAN, N

机构：

[1] UNIV WASHINGTON,DEPT PHARMACOL,SEATTLE,WA 98195

[2] UNIV TORONTO,DEPT BIOCHEM,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1987年 / 84卷 / 23期

关键词：

D O I：

10.1073/pnas.84.23.8239

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：8239 / 8242

页数：4

共 8 条

[1] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].

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DECLERCQ, E ;

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VANDEPUTTE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) :128-134

[2] MOLECULAR-STRUCTURE OF A DEOXYRIBOSE-DINUCLEOTIDE, SODIUM THYMIDYLYL-(5'-]3')-THYMIDYLATE-(5') HYDRATE (PTPT), AND A POSSIBLE STRUCTURAL MODEL FOR POLYTHYMIDYLATE [J].

CAMERMAN, N ;

FAWCETT, JK ;

CAMERMAN, A .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 107 (04) :601-621

[3] PHOSPHORYLATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND SELECTIVE INTERACTION OF THE 5'-TRIPHOSPHATE WITH HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

FURMAN, PA ;

FYFE, JA ;

STCLAIR, MH ;

WEINHOLD, K ;

RIDEOUT, JL ;

FREEMAN, GA ;

LEHRMAN, SN ;

BOLOGNESI, DP ;

BRODER, S ;

MITSUYA, H ;

BARRY, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8333-8337

[4] IMMINENT MARKETING OF AZT RAISES PROBLEMS [J].

KOLATA, G .

SCIENCE, 1987, 235 (4795) :1462-1463

[5] 3'-AZIDO-3'-DEOXYTHYMIDINE (BW A509U) - AN ANTIVIRAL AGENT THAT INHIBITS THE INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS INVITRO [J].

MITSUYA, H ;

WEINHOLD, KJ ;

FURMAN, PA ;

STCLAIR, MH ;

LEHRMAN, SN ;

GALLO, RC ;

BOLOGNESI, D ;

BARRY, DW ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7096-7100

[6] INHIBITION OF REVERSE-TRANSCRIPTASE ACTIVITY BY 2',3'-DIDEOXYTHYMIDINE 5'-TRIPHOSPHATE AND ITS DERIVATIVES MODIFIED ON THE 3' POSITION [J].

ONO, K ;

OGASAWARA, M ;

IWATA, Y ;

NAKANE, H ;

FUJII, T ;

SAWAI, K ;

SANEYOSHI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 140 (02) :498-507

[7]

St Clair M. H., 1985, 25TH INT C ANT AG CH, P439

[8]

YARCHOAN R, 1986, LANCET, V1, P575

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