FUNGUS-SPECIFIC TRANSLATION ELONGATION FACTOR-III GENE PRESENT IN PNEUMOCYSTIS-CARINII

被引:73
作者
YPMAWONG, MF [1 ]
FONZI, WA [1 ]
SYPHERD, PS [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717
关键词
D O I
10.1128/IAI.60.10.4140-4145.1992
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Historically, Pneumocystis carinii pneumonia has been the most frequent cause of morbidity and mortality in patients with AIDS. Antiprotozoan drugs are effective in the treatment and prophylaxis of P. carinii pneumonia, which lends credence to the widely held view that P. carinii is a protozoan. However, recent genetic evidence suggests that P. carinii should be classified as a fungus. Translation elongation factor 3 (EF-3) is an essential, soluble translation component which is unique to fungal protein synthesis and is not required for protein synthesis in other eukaryotes. We have identified and isolated a gene for EF-3 from P. carinii, adding more evidence for this organism's assignment as a fungus.
引用
收藏
页码:4140 / 4145
页数:6
相关论文
共 32 条
  • [21] QIN SL, 1990, J BIOL CHEM, V265, P1903
  • [22] SANDBAKEN MG, 1990, J BIOL CHEM, V265, P15838
  • [23] SANDERSLAUFER D, 1991, PEDIATR CLIN N AM, V38, P69
  • [24] Skogerson L, 1979, Methods Enzymol, V60, P676
  • [25] SKOGERSON L, 1977, J BIOL CHEM, V252, P1471
  • [26] RIBOSOME-DEPENDENT GTPASE FROM YEAST DISTINCT FROM ELONGATION FACTOR-2
    SKOGERSON, L
    WAKATAMA, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) : 73 - 76
  • [27] URITANI M, 1988, INT J BIOCHEM, V20, P581
  • [28] MICROTUBULES IN PNEUMOCYSTIS-CARINII
    VOSSEN, MEMH
    BECKERS, PJA
    MEUWISSEN, JHET
    STADHOUDERS, AM
    [J]. ZEITSCHRIFT FUR PARASITENKUNDE-PARASITOLOGY RESEARCH, 1976, 49 (03): : 291 - 292
  • [29] IMMUNOCYTOCHEMICAL DETECTION OF CHITIN IN PNEUMOCYSTIS-CARINII
    WALKER, AN
    GARNER, RE
    HORST, MN
    [J]. INFECTION AND IMMUNITY, 1990, 58 (02) : 412 - 415
  • [30] PNEUMOCYSTIS-CARINII - FREEZE-FRACTURE STUDY OF STAGES OF THE ORGANISM
    YONEDA, K
    WALZER, PD
    RICHEY, CS
    BIRK, MG
    [J]. EXPERIMENTAL PARASITOLOGY, 1982, 53 (01) : 68 - 76