CENTRALLY ACTIVE MODULATORS OF GLUTAMATE RECEPTORS FACILITATE THE INDUCTION OF LONG-TERM POTENTIATION IN-VIVO

被引:144
作者
STAUBLI, U
PEREZ, Y
XU, FB
ROGERS, G
INGVAR, M
STONEELANDER, S
LYNCH, G
机构
[1] UNIV CALIF SANTA BARBARA,NEUROSCI RES INST,SANTA BARBARA,CA 93106
[2] KAROLINSKA HOSP,S-1040 STOCKHOLM,SWEDEN
[3] UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY,IRVINE,CA 92717
关键词
D O I
10.1073/pnas.91.23.11158
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an analogue of 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine that was also found to improve retention of memory in a radial maze task and in an odor-matching problem. These results define tools for enhancing long-term potentiation in vivo and confirm an important prediction from the hypothesis that long-term potentiation is a substrate of memory.
引用
收藏
页码:11158 / 11162
页数:5
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