A CENTRALLY ACTIVE-DRUG THAT MODULATES AMPA RECEPTOR GATED CURRENTS

被引：115

作者：

ARAI, A ^{[1
]}

KESSLER, M ^{[1
]}

XIAO, P ^{[1
]}

AMBROSINGERSON, J ^{[1
]}

ROGERS, G ^{[1
]}

LYNCH, G ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA,NEUROSCI RES INST,SANTA BARBARA,CA 93106

来源：

BRAIN RESEARCH | 1994年 / 638卷 / 1-2期

关键词：

AMPA RECEPTOR; EXCISED PATCH; HIPPOCAMPUS; 1-(1,3-BENZODIOXOL-5-YLCARBONYL)-PIPERIDINE (1-BCP);

D O I：

10.1016/0006-8993(94)90669-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systemic administration of the drug 1-(1,3-benzodioxol-5-ylcarbonyl)-piperidine (1-BCP) has been reported to enhance monosynaptic responses in the hippocampus in vivo and to improve spatial and olfactory memory in rats. The drug's mechanism of action was investigated in the present study using membrane patches excised from cultured hippocampal slices. The decay time of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor mediated inward currents was greatly increased by 1-BCP in a concentration dependent and reversible fashion; peak current was also enhanced but to a lesser degree. In vitro slice experiments indicated that the drug has parallel effects on the field EPSP. It is concluded that 1-BCP is a centrally active modulator of the AMPA receptor.

引用

页码：343 / 346

页数：4

共 5 条

[1] ALLOSTERIC POTENTIATION OF QUISQUALATE RECEPTORS BY A NOOTROPIC DRUG ANIRACETAM
ITO, I
TANABE, S
KOHDA, A
SUGIYAMA, H
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 424 : 533 - 543
[2] INDUCTION OF SYNAPTIC POTENTIATION IN HIPPOCAMPUS BY PATTERNED STIMULATION INVOLVES 2 EVENTS
LARSON, J
LYNCH, G
[J]. SCIENCE, 1986, 232 (4753) : 985 - 988
[3] FACILITATION OF THE INDUCTION OF LONG-TERM POTENTIATION BY GABA-B RECEPTORS
MOTT, DD
LEWIS, DV
[J]. SCIENCE, 1991, 252 (5013) : 1718 - 1720
[4] STAUBLI U, 1994, IN PRESS P NAT ACAD
[5] A SIMPLE METHOD FOR ORGANOTYPIC CULTURES OF NERVOUS-TISSUE
STOPPINI, L
BUCHS, PA
MULLER, D
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1991, 37 (02) : 173 - 182

← 1 →